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KMID : 1161420110140030226
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Journal of Medicinal Food
2011 Volume.14 No. 3 p.226 ~ p.231
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Effects of Typheramide and Alfrutamide Found in Allium Species on Cyclooxygenases and Lipoxygenases
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Park Jae-B.
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Abstract
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Typheramide (N-caffeoyltyramine) and alfrutamide (N-feruloyltyramine) are phenylpropenoic acid amides found in plants. In this article, typheramide and alfrutamide were isolated from Allium sativum (garlic) and Allium fistulosum (green onion), their chemical structures were confirmed using nuclear magnetic resonance spectroscopic methods, and the potential effects on cyclooxygenases (COXs) (COX 1 and 2) and lipoxygenases (LOXs) (5- and 15-LOX) were investigated. Typheramide and alfrutamide inhibited COX 1 by 74% (P?
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KEYWORD
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alfrutamide, Allium fistulosum (green onion), Allium sativum (garlic), cyclooxygenase inhibition, lipoxygenase, typheramide
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